A randomized trial comparing colchicine and ursodeoxycholic acid combination to ursodeoxycholic acid in primary biliary cirrhosis
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چکیده
منابع مشابه
A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis.
One hundred fifty-one patients with primary biliary cirrhosis (PBC) grouped into four strata based on entry serum bilirubin ( < 2 mg/dL vs. 2 md/dL or greater) and liver histology (stages I, II vs. stages III, IV-Ludwig criteria) were randomized within each stratum to ursodiol or placebo given in a single dose of 10 to 12 mg/kg at bedtime for 2 years. Placebo- (n = 74) and ursodiol- treated (n ...
متن کاملThe ursodeoxycholic acid story in primary biliary cirrhosis.
The ursodeoxycholic acid story in primary biliary cirrhosis The name ursodeoxycholic acid (UDCA) is derived from 'ursocholeinische saure' used by Hammarsten in 1902 to describe a bile acid discovered in polar bears. The bile acid he identified was actually chenodeoxycholic acid.1 UDCA is the 7P epimer of chenodeoxycholic acid and has the chemical structure 3a 7,B-dihydroxy-5p-cholan-24-oic acid...
متن کاملCost-effectiveness of ursodeoxycholic acid therapy in primary biliary cirrhosis.
Ursodeoxycholic acid (UDCA) is a safe and effective treatment for patients with primary biliary cirrhosis (PBC), but the cost of this drug has raised concerns regarding cost-effectiveness. The aim of our study was to determine the cost-effectiveness of UDCA in PBC. We compared the costs and outcomes of managing PBC patients with and without UDCA. From two previously published trials, the effect...
متن کامل[Treatment of primary biliary cirrhosis with ursodeoxycholic acid].
This study was undertaken to evaluate the efficacy of ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis (PBC). Three patients with PBC (stage II) have been treated with UDCA (Ursofalk and Falk Pharma, Freiburg, Germany)--of 10 mg/kg daily dosage in the course of three years. Patients with well-defined PBC underwent complete history, physical examination, liver chemistrie...
متن کاملEfficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.
BACKGROUND & AIMS We evaluated the efficacy and safety of obeticholic acid (OCA, α-ethylchenodeoxycholic acid) in a randomized controlled trial of patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic acid therapy. METHODS We performed a double-blind study of 165 patients with primary biliary cirrhosis (95% women) and levels of alkaline phosphatase (ALP) 1....
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ژورنال
عنوان ژورنال: Hepatology
سال: 1996
ISSN: 0270-9139
DOI: 10.1053/jhep.1996.v24.pm0008903382